Natural products (secondary metabolites) have been the most successful source of leads for potential drug discovery. Natural products have been well documented for their medicinal uses for thousands of years. Plants have evolved and adapted over millions of years to withstand bacteria, insects, fungi and weather to produce unique, structurally diverse secondary metabolites. Their ethno pharmacological properties have been used as a primary source of medicines for early drug discovery. Macro and micro fungi have been part of human life for thousands of years. They were used as food (mushrooms), in preparation of alcoholic beverages (yeasts), medication in traditional medicine and for cultural purposes